1. The Evolution of Anti-Aging Dermatology Treatments

According to a professional medical column published by Mediafine, dermatological anti-aging treatments are no longer limited to simple moisturization or volume enhancement. As the focus shifts toward overall improvement of skin condition, increasing attention is being paid to fourth-generation skin boosters such as Elreju (ELREJU).

Anti-aging has entered a new chapter: ELREJU- fourth-generation skin boosters.

2. PDRN: A Clinically Proven Skin Regeneration Ingredient

One of the key active ingredients in Elreju is PDRN (Polydeoxyribonucleotide), a component with a long history of use in regenerative medicine and widespread application in cosmetic formulations. However, in clinical practice, delivering PDRN into the skin through medical procedures is considered more effective than topical application to the skin surface.

PDRN in ELREJU works more effectively when injected into the skin, supporting deeper regeneration.

3. Scientific Evidence and Targeted Delivery Technology

A research paper titled “Injectable Skin Boosters in Aging Skin Rejuvenation,” published online in the second half of 2024 in an international academic journal, provided clinical evidence that various injectable skin boosters can positively impact skin hydration and elasticity.

Skin booster treatments work by penetrating the skin barrier and delivering active ingredients directly to targeted areas. In Elreju procedures, devices such as MTS and Potenza pumping tips are used to inject PDRN, PN (Polynucleotides), and hybrid hyaluronic acid into the dermal layer, improving the efficiency of active ingredient delivery.

4. The Dermal Layer: A New Standard in Skin Regeneration

Diagram of Human Skin Structure

For PDRN to function effectively, it must reach the dermal layer, where fibroblasts responsible for collagen and elastin production are concentrated. The dermis accounts for most of the skin’s thickness and plays a crucial role in skin hydration retention and elasticity.

To fully realize the regenerative effects of PDRN, skin boosters such as Elreju, Juvelook, and exosomes are used in combination with microneedling techniques to directly stimulate dermal fibroblasts.

As of 2026, PDRN has moved beyond a temporary trend and is now recognized as a scientifically validated ingredient in both the Korean and global skincare markets. Advanced treatment options that enhance delivery precision—such as fourth-generation skin boosters like Elreju—are emerging as a new benchmark in skin regeneration therapy.
(Dr. Shin Yong-bae, Chief Medical Director, Dr. Newcell Clinic Gangnam)

5. Dr. Beau’s Note

Elreju (ELREJU) is a fourth-generation skin booster reflecting the shift toward comprehensive skin quality improvement in anti-aging treatments. PDRN, its key regenerative ingredient, delivers optimal results when injected directly into the dermal layer through advanced procedures. By combining microneedling with high-precision devices, Elreju sets a new standard in modern skin regeneration therapy.

6. Frequently Asked Questions

How is Elreju different from traditional skin boosters?

As a fourth-generation skin booster, Elreju focuses on precise dermal delivery of regenerative ingredients rather than temporary hydration or volume effects.

Are the results natural-looking?

Yes. Elreju enhances the skin’s natural regenerative process, resulting in gradual and subtle improvements rather than artificial-looking changes.